Jump to main content
Jump to site search


A highly sensitive red-emitting probe for the detection of viscosity changes in living cells, zebrafish, and human blood samples

Author affiliations

Abstract

Intracellular viscosity can be measured to reflect the state of living cells. Fluorescent probes are powerful tools for viscosity detection in vivo. Herein, we report on a novel red-emitting viscosity-sensitive probe DJH with a large Stokes shift of 165 nm, showing a 400-fold fluorescence enhancement from PBS solution to 90% glycerol. The probe was suitable for the visualization of the changes in viscosity within living cells and also in zebrafish treated with microplastics for the first time. Furthermore, the viscosity of fresh blood from diabetic mice and hypertensive and diabetic patients was first evaluated by using DJH. These results showed that the probe has a wide range of potential applications in basic research on environmental pollution and in the pre-diagnosis of patients.

Graphical abstract: A highly sensitive red-emitting probe for the detection of viscosity changes in living cells, zebrafish, and human blood samples

Back to tab navigation

Supplementary files

Article information


Submitted
17 Sep 2019
Accepted
23 Dec 2019
First published
30 Dec 2019

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

A highly sensitive red-emitting probe for the detection of viscosity changes in living cells, zebrafish, and human blood samples

M. Fu, W. Shen, Y. Chen, W. Yi, C. Cai, L. Zhu and Q. Zhu, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02023C

Social activity

Search articles by author

Spotlight

Advertisements