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Oroxylin A-loaded aggregation-induced emission polymeric system greatly increased the antitumor efficacy against squamous cell carcinoma

Abstract

The squamous cell carcinoma (SCC) is a nonmelanoma cancer of the skin that usually suffered from poor therapeutic benefits while oroxylin A (OA) is a promising flavonoid with high anticancer efficacy on various cancer types. Here in our study, in order to reveal the potential of OA based drug delivery system (DDS) on the treatment of SCC, we firstly revealed that OA had a certain pharmacodynamic effect on skin SCC (A431 cells). Afterwards, OA was loaded into a newly synthesized aggregation-induced emission (AIE) polymer to construct OA-loaded PDots for the first time. Our results revealed that OA-loaded PDots showed preferable drug loading and enhanced stability. Moreover, the DDS also capable of self-illuminating under aggregate state to reveal the uptake profile. Most importantly, the DDS showed much more elevated anticancer benefits than free OA in vitro and advanced tumor targetability in vivo, which might be a promising system against SCC.

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Supplementary files

Article information


Submitted
25 Aug 2019
Accepted
27 Jan 2020
First published
29 Jan 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

Oroxylin A-loaded aggregation-induced emission polymeric system greatly increased the antitumor efficacy against squamous cell carcinoma

Y. Zhu, Y. Guo, M. Liu, L. Wei and X. Wang, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB01818B

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