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WS2 nanosheets functionalized by biomimetic lipids with enhanced dispersibility for photothermal and chemo combination therapy

Abstract

Multi-component combination therapy of cancer is currently a hot spot in the field of cancer treatment research. In this study, WS2 nanosheet was selected as the substrate material and modified with cell-like membrane biomimetic liposome (WS2-lipid). The lipid-modified WS2 nanomaterials were successfully prepared with good stability and biocompatibility. Its good photothermal characteristics and high drug loading amount were utilized to achieve a comprehensive chemo and photothermal therapeutic effect. The results showed that the lipid coating strongly enhanced the stability of WS2 nanosheets before and after DOX loading and WS2-lipid had a good photothermal performance and drug loading amount. According to the cellular results, WS2-lipid was able to be uptaken by MCF-7 cells. Both photothermo therapy and chemotherapy had a concentration dependent cytotoxicity on MCF-7 cells, and the combined application of both methods had an improved cytotoxicity. In addition, in vivo photothermal experiments indicated lipid modification could promote intratumoral accumulation of the material. Thus, WS2-lipid can be used as a good nano-platform for phototherapy and chemotherapy combination therapy, and has a good application prospect in cancer therapy.

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Supplementary files

Article information


Submitted
01 Aug 2019
Accepted
29 Jan 2020
First published
03 Feb 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

WS2 nanosheets functionalized by biomimetic lipids with enhanced dispersibility for photothermal and chemo combination therapy

M. Xie, M. Yang, X. Sun, N. Yang, T. Deng, Y. Li and H. Shen, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB01604J

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