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Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

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Abstract

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP–polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

Graphical abstract: Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

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Supplementary files

Article information


Submitted
19 Apr 2020
Accepted
09 Jun 2020
First published
10 Jun 2020

Soft Matter, 2020, Advance Article
Article type
Paper

Hybrid GMP–polyamine hydrogels as new biocompatible materials for drug encapsulation

A. Lopera, J. A. Aguilar, R. Belda, B. Verdejo, J. W. Steed and E. García-España, Soft Matter, 2020, Advance Article , DOI: 10.1039/D0SM00704H

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