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A mathematical finance approach to the stochastic and intermittent viscosity fluctuations in living cells

Abstract

Here we report on the viscosity of eukaryotic living cells as a function of the time, and on the appli-cation of stochastic models to analyze its temporal fluctuations. The viscoelastic properties of NIH/3T3 fibroblastic cells are investigated using an active microrheological technique, where mag-netic wires, embedded into cells, are being actuated remotely. The data reveal anomalous transient responses characterized by intermittent phases of slow and fast rotation, leading to significant fluc-tuations. The time dependent viscosity is analyzed from a time series perspective by computing the autocorrelation functions and the variograms, two functions used to describe stochastic processes in mathematical finance. The resulting analysis gives evidence of a sub-diffusive mean-reverting pro-cess characterized by an autoregressive coefficient lower than 1. It also shows the existence of spe-cific cellular times in the ranges 1 - 10 s and 100 - 200 s, not previously disclosed. The shorter time is found being related to the internal relaxation time of the cytoplasm. To our knowledge, this is the first time that similarities are established between the properties of time series describing the intracel-lular metabolism and statistical results from mathematical finance. The current approach could be exploited to reveal hidden features from biological complex systems, or determine new biomarkers of cellular metabolism.

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Supplementary files

Article information


Submitted
28 Dec 2019
Accepted
16 May 2020
First published
18 May 2020

Soft Matter, 2020, Accepted Manuscript
Article type
Paper

A mathematical finance approach to the stochastic and intermittent viscosity fluctuations in living cells

C. L. Bostoen and J. Berret, Soft Matter, 2020, Accepted Manuscript , DOI: 10.1039/C9SM02534K

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