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Membrane morphologies induced by mixtures of arc-shaped particles with opposite curvature

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Abstract

Biological membranes are shaped by various proteins that either generate inward or outward membrane curvature. In this article, we investigate the membrane morphologies induced by mixtures of arc-shaped particles with coarse-grained modeling and simulations. The particles bind to the membranes either with their inward, concave side or their outward, convex side and, thus, generate membrane curvature of opposite sign. We find that small fractions of convex-binding particles can stabilize three-way junctions of membrane tubules, as suggested for the protein lunapark in the endoplasmic reticulum of cells. For comparable fractions of concave-binding and convex-binding particles, we observe lines of particles of the same type, and diverse membrane morphologies with grooves and bulges induced by these particle lines. The alignment and segregation of the particles is driven by indirect, membrane-mediated interactions.

Graphical abstract: Membrane morphologies induced by mixtures of arc-shaped particles with opposite curvature

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Article information


Submitted
18 Dec 2019
Accepted
01 Apr 2020
First published
02 Apr 2020

This article is Open Access

Soft Matter, 2020, Advance Article
Article type
Paper

Membrane morphologies induced by mixtures of arc-shaped particles with opposite curvature

F. Bonazzi, C. K. Hall and T. R. Weikl, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM02476J

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