Jump to main content
Jump to site search


Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations

Author affiliations

Abstract

Tissues transition between solid-like and fluid-like behavior, which has major implications for morphogenesis and disease. These transitions can occur due to changes in the intrinsic shape of constituent cells and cell motility. We consider an alternative mechanism by studying tissues that explore the energy landscape through stochastic dynamics, driven by turnover of junctional molecular motors. To identify the solid–fluid transition, we start with single-component tissues and show that the mean cell-shape index uniquely describes the effective diffusion coefficient of cell movements, which becomes finite at the transition. We generalize our approach to two-component tissues, and explore cell-sorting dynamics both due to differential adhesion and due to differential degree of junctional fluctuations. We recover some known characteristic scaling relations describing the sorting kinetics, and discover some discrepancies from these relations in the case of differential-fluctuations-driven sorting. Finally, we show that differential fluctuations efficiently sort two solid-like tissues with a fluid intercompartmental boundary.

Graphical abstract: Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations

Back to tab navigation

Supplementary files

Article information


Submitted
22 Nov 2019
Accepted
03 Mar 2020
First published
11 Mar 2020

Soft Matter, 2020, Advance Article
Article type
Paper

Solid–fluid transition and cell sorting in epithelia with junctional tension fluctuations

M. Krajnc, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM02310K

Social activity

Search articles by author

Spotlight

Advertisements