Jump to main content
Jump to site search


Dipolar Janus liposomes: formation, electrokinetic motion and self-assembly

Author affiliations

Abstract

Presented herein is the first report on dipolar Janus liposomes–liposomes that contain opposite surface charges decorating the two hemispheres of the same colloidal body. Such heterogeneous organization of surface charge is achieved through cholesterol-modulated lipid phase separation, which sorts anionic/cationic lipids into coexisting liquid-ordered/liquid-disordered domains. We present optimized experimental conditions to produce these liposomes in high yields, based on the gel-assisted hydration of ternary lipid systems consisting of cholesterol, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, and 1,2-dioleoyl-sn-glycero-3-phosphocholine. The size/charge distribution and domain configuration of these liposomes are characterized in detail by confocal fluorescence microscopy, nanosphere binding and zeta potential measurements. Using confocal fluorescence microscopy, we also follow the electrokinetic motion as well as the electrostatic self-assembly of these new dipolar Janus particles.

Graphical abstract: Dipolar Janus liposomes: formation, electrokinetic motion and self-assembly

Back to tab navigation

Supplementary files

Article information


Submitted
13 Nov 2019
Accepted
20 Jan 2020
First published
21 Jan 2020

Soft Matter, 2020, Advance Article
Article type
Communication

Dipolar Janus liposomes: formation, electrokinetic motion and self-assembly

Z. Liu, J. Cui and W. Zhan, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM02254F

Social activity

Search articles by author

Spotlight

Advertisements