Issue 13, 2020
From the journal:

Soft Matter

Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties†

Wiktor Kasprzyk, ORCID logo *a   Szczepan Bednarz, ORCID logo a   Dariusz Bogdał, ORCID logo a   Guillermo A. Ameer ORCID logo b  and  Tomasz Świergosz ORCID logo c  

* Corresponding authors

a Department of Biotechnology and Physical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31-155 Kraków, Poland
E-mail: wiktor.kasprzyk@pk.edu.pl

b Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA

c Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31-155 Kraków, Poland

Abstract

Herein, we describe the synthesis of poly(1,8-octamethylene citrate) materials modified in the bulk with 2-hydroxypropyl-β-cyclodextrin (cPOCCD), biodegradable elastomers with intrinsic sorption properties for drug delivery. The chemical structure, physicochemical properties, in vitro drug loading and release profiles of cPOCCD were investigated. Thus, cPOCCD polyesters absorb the studied drugs more effective and release them for a longer period of time than poly(1,8-octamethylene citrate) materials not containing cyclodextrins.

Graphical abstract: Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties

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Article information

DOI
https://doi.org/10.1039/C9SM02075F
Article type
Paper
Submitted
18 Oct 2019
Accepted
02 Mar 2020
First published
02 Mar 2020

Soft Matter, 2020,16, 3311-3318

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Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties

W. Kasprzyk, S. Bednarz, D. Bogdał, G. A. Ameer and T. Świergosz, Soft Matter, 2020, 16, 3311 DOI: 10.1039/C9SM02075F

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