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Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties

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Abstract

Herein, we describe the synthesis of poly(1,8-octamethylene citrate) materials modified in the bulk with 2-hydroxypropyl-β-cyclodextrin (cPOCCD), biodegradable elastomers with intrinsic sorption properties for drug delivery. The chemical structure, physicochemical properties, in vitro drug loading and release profiles of cPOCCD were investigated. Thus, cPOCCD polyesters absorb the studied drugs more effective and release them for a longer period of time than poly(1,8-octamethylene citrate) materials not containing cyclodextrins.

Graphical abstract: Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties

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Article information


Submitted
18 Oct 2019
Accepted
02 Mar 2020
First published
02 Mar 2020

Soft Matter, 2020, Advance Article
Article type
Paper

Cyclodextrin-modified poly(octamethylene citrate) polymers towards enhanced sorption properties

W. Kasprzyk, S. Bednarz, D. Bogdał, G. A. Ameer and T. Świergosz, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM02075F

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