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Tuning molecular motor transport through cytoskeletal filament network organization

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Abstract

Within cells, crosslinking proteins organize cytoskeletal filaments both temporally and spatially to create dynamic and structurally diverse networks. Molecular motors move on these networks for both force generation and transport processes. How the transport statistics depend on the network architecture remains poorly characterized. Using cross-linking proteins (α-actinin, fimbrin, fascin, or filamin) and purified actin, we create cytoskeletal networks with diverse microscopic architectures. We track the motion of myosin II motor proteins moving on these networks and calculate transport statistics. We observe that motor dynamics change predictably based on the bundling of filaments within the underlying networks and discuss implications for network function.

Graphical abstract: Tuning molecular motor transport through cytoskeletal filament network organization

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Article information


Submitted
20 Sep 2019
Accepted
23 Jan 2020
First published
24 Jan 2020

Soft Matter, 2020, Advance Article
Article type
Paper

Tuning molecular motor transport through cytoskeletal filament network organization

M. Scholz, K. L. Weirich, M. L. Gardel and A. R. Dinner, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM01904A

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