Issue 4, 2020

Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin

Abstract

We report results from full atomistic molecular dynamics simulations on the properties of biomimetic nanopores. This latter result was obtained through the direct insertion of an α-hemolysin protein inside a hydrophobic solid-state nanopore. Upon translocation of different DNA strands, we demonstrate here that the theoretical system presents the same discrimination properties as the experimental one obtained previously. This opens an interesting way to promote the stability of a specific protein inside a solid nanopore to develop further biomimetic applications for DNA or protein sequencing.

Graphical abstract: Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin

Supplementary files

Article information

Article type
Paper
Submitted
11 Sep 2019
Accepted
04 Dec 2019
First published
05 Dec 2019

Soft Matter, 2020,16, 1002-1010

Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin

J. Bentin, S. Balme and F. Picaud, Soft Matter, 2020, 16, 1002 DOI: 10.1039/C9SM01833F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements