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Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin

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Abstract

We report results from full atomistic molecular dynamics simulations on the properties of biomimetic nanopores. This latter result was obtained through the direct insertion of an α-hemolysin protein inside a hydrophobic solid-state nanopore. Upon translocation of different DNA strands, we demonstrate here that the theoretical system presents the same discrimination properties as the experimental one obtained previously. This opens an interesting way to promote the stability of a specific protein inside a solid nanopore to develop further biomimetic applications for DNA or protein sequencing.

Graphical abstract: Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin

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Article information


Submitted
11 Sep 2019
Accepted
04 Dec 2019
First published
05 Dec 2019

Soft Matter, 2020, Advance Article
Article type
Paper

Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin

J. Bentin, S. Balme and F. Picaud, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM01833F

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