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Thermal fracture kinetics of heterogeneous semiflexible polymers

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Abstract

The fracture and severing of polymer chains plays a critical role in the failure of fibrous materials and the regulated turnover of intracellular filaments. Using continuum wormlike chain models, we investigate the fracture of semiflexible polymers via thermal bending fluctuations, focusing on the role of filament flexibility and dynamics. Our results highlight a previously unappreciated consequence of mechanical heterogeneity in the filament, which enhances the rate of thermal fragmentation particularly in cases where constraints hinder the movement of the chain ends. Although generally applicable to semiflexible chains with regions of different bending stiffness, the model is motivated by a specific biophysical system: the enhanced severing of actin filaments at the boundary between stiff bare regions and mechanically softened regions that are coated with cofilin regulatory proteins. The results presented here point to a potential mechanism for disassembly of polymeric materials in general and cytoskeletal actin networks in particular by the introduction of locally softened chain regions, as occurs with cofilin binding.

Graphical abstract: Thermal fracture kinetics of heterogeneous semiflexible polymers

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Article information


Submitted
12 Aug 2019
Accepted
20 Jan 2020
First published
22 Jan 2020

Soft Matter, 2020, Advance Article
Article type
Paper

Thermal fracture kinetics of heterogeneous semiflexible polymers

A. M. Lorenzo, E. M. De La Cruz and E. F. Koslover, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM01637F

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