Issue 46, 2020

Synthetic half-reactions


This perspective on reactivity introduces Synthetic Half-Reactions (SHRs) as a way to analyze chemical transformations. SHRs denote either an uphill transformation leading to a higher energy state or a downhill transformation leading to a lower energy state. Using well-established processes, I show how the matching of different classes of SHRs offers a tool to classify chemical transformations. This raises the possibility to discover new processes by finding underappreciated combinations of endergonic and exergonic steps.

Graphical abstract: Synthetic half-reactions

Article information

Article type
15 Jul 2020
06 Sep 2020
First published
09 Sep 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 12423-12427

Synthetic half-reactions

A. K. Yudin, Chem. Sci., 2020, 11, 12423 DOI: 10.1039/D0SC03876H

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