Issue 31, 2020

Rational design of an “all-in-one” phototheranostic


We report here porphodilactol derivatives and their corresponding metal complexes. These systems show promise as “all-in-one” phototheranostics and are predicated on a design strategy that involves controlling the relationship between intersystem crossing (ISC) and photothermal conversion efficiency following photoexcitation. The requisite balance was achieved by tuning the aromaticity of these porphyrinoid derivatives and forming complexes with one of two lanthanide cations, namely Gd3+ and Lu3+. The net result led to a metalloporphodilactol system, Gd-trans-2, with seemingly optimal ISC efficiency, photothermal conversion efficiency and fluorescence properties, as well as good chemical stability. Encapsulation of Gd-trans-2 within mesoporous silica nanoparticles (MSN) allowed its evaluation for tumour diagnosis and therapy. It was found to be effective as an “all-in-one” phototheranostic that allowed for NIR fluorescence/photoacoustic dual-modal imaging while providing an excellent combined PTT/PDT therapeutic efficacy in vitro and in vivo in 4T1-tumour-bearing mice.

Graphical abstract: Rational design of an “all-in-one” phototheranostic

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Article information

Article type
Edge Article
17 Jun 2020
18 Jul 2020
First published
21 Jul 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 8204-8213

Rational design of an “all-in-one” phototheranostic

Z. Yang, Y. Yao, A. C. Sedgwick, C. Li, Y. Xia, Y. Wang, L. Kang, H. Su, B. Wang, S. Gao, J. L. Sessler and J. Zhang, Chem. Sci., 2020, 11, 8204 DOI: 10.1039/D0SC03368E

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