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Issue 21, 2020
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Covalent organic frameworks as micro-reactors: confinement-enhanced electrochemiluminescence

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Abstract

Electrochemiluminescence (ECL) micro-reactors with enhanced intensity and extreme stability were first established by the assembly of tris(2,2′-bipyridyl) ruthenium(II) (Ru(bpy)32+) onto covalent organic frameworks (COFs), in which a type of imine-linked COF (denoted as COF-LZU1) was employed as a model for ECL micro-reactors. Compared with the dominant ECL system of Ru(bpy)32+/tri-n-propylamine (TPrA) (TPrA as a co-reactant), the intensity of the COF-LZU1 micro-reactor-based electrode was significantly increased nearly 5-fold under the same experimental conditions, which is unprecedented in other Ru(bpy)32+-based ECL systems. This enhancement can be attributed to the large surface area, delimited space, and stable and hydrophobic porous structure of COF-LZU1, which not only enabled a huge amount of Ru(bpy)32+ to be loaded in/on COF-LZU1, but also enriched a large amount of TPrA from the aqueous solution into its inner hydrophobic cavity due to the lipophilicity of TPrA. More importantly, with its hydrophobic porous nanochannels, COF-LZU1 could act as micro-reactors to provide a delimited reaction micro-environment for the electrochemical oxidation of TPrA and the survival of TPrA˙, achieving significant confinement-enhanced ECL. To prove this principle, these Ru@COF-LZU1 micro-reactors were developed to prepare an ECL aptasensor for aflatoxin M1 (AFM1) detection with a wide detection range and a low detection limit. Overall, this work is the first report in which ECL micro-reactors are constructed with COFs to enhance the intensity and stability of the Ru(bpy)32+-based ECL system, and opens a new route to the design of other ECL micro-reactors for bioanalysis applications.

Graphical abstract: Covalent organic frameworks as micro-reactors: confinement-enhanced electrochemiluminescence

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Supplementary files

Article information


Submitted
30 Mar 2020
Accepted
29 Apr 2020
First published
30 Apr 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 5410-5414
Article type
Edge Article

Covalent organic frameworks as micro-reactors: confinement-enhanced electrochemiluminescence

W. Zeng, K. Wang, W. Liang, Y. Chai, R. Yuan and Y. Zhuo, Chem. Sci., 2020, 11, 5410
DOI: 10.1039/D0SC01817A

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