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“CLipP”ing on lipids to generate antibacterial lipopeptides

Abstract

We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel “CLipP”ed lipopeptides exhibited low micromolar MICs and MBCs against both Gram-negative and Gram-positive bacteria.

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Article information


Submitted
30 Mar 2020
Accepted
20 May 2020
First published
20 May 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Accepted Manuscript
Article type
Edge Article

“CLipP”ing on lipids to generate antibacterial lipopeptides

V. Yim, P. Harris, M. A. Brimble, J. R. Allison, A. Chakraborty, S. Swift, A. Cameron, S. A. Ferguson, M. K. Knottenbelt, I. Kavianinia and G. Cook, Chem. Sci., 2020, Accepted Manuscript , DOI: 10.1039/D0SC01814G

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