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Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens

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Abstract

Cancer cell discrimination and cellular viability monitoring are closely related to human health. A universal and convenient fluorescence system with a dual function of wide-spectrum cancer cell discrimination and dynamic cellular viability monitoring is desperately needed, and is still extremely challenging. Herein we present a series of aggregation-induced emission luminogens (AIEgens) (denoted as IVP) which can allow accurate discrimination between cancer and normal cells and dynamic monitoring of cellular viability through mitochondria–nucleolus migration. By regulating the lengths and positions of alkyl chains in IVP molecules, we systematically studied the discrimination behavior of these AIEgens between cancer cells and normal cells and further investigated how they can migrate between the mitochondria and nucleolus based on the change of mitochondrial membrane potential (ΔΨm). Using IVP-02 as a model molecule, wash-free bioimaging, excellent two-photon properties, and low cytotoxicity were demonstrated. This present work proves that these designed IVP AIEgens show great potential for cancer identification and metastasis monitoring, as well as activity evaluation and screening of drugs.

Graphical abstract: Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens

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Supplementary files

Article information


Submitted
28 Feb 2020
Accepted
29 Apr 2020
First published
30 Apr 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Advance Article
Article type
Edge Article

Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens

R. Zhang, G. Niu, Q. Lu, X. Huang, J. H. C. Chau, R. T. K. Kwok, X. Yu, M. Li, J. W. Y. Lam and B. Z. Tang, Chem. Sci., 2020, Advance Article , DOI: 10.1039/D0SC01213K

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