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Synthesis of azetidines by aza Paternò–Büchi reactions

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Abstract

The [2 + 2] photocycloaddition reaction between an imine and an alkene component, the aza Paternò–Büchi reaction, is one of the most efficient ways to synthesize functionalized azetidines. However, the application of the aza Paternò–Büchi reaction has been met with limited success due to the inherent challenges associated with this approach. This review covers the current scope and limitations of reported examples of aza Paternò–Büchi reactions in organic synthesis. An outlook is provided, which highlights recent improvements and the discovery of new reaction protocols that have overcome some long-standing challenges within this field of research.

Graphical abstract: Synthesis of azetidines by aza Paternò–Büchi reactions

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Article information


Submitted
20 Feb 2020
Accepted
06 May 2020
First published
12 Jun 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Advance Article
Article type
Minireview

Synthesis of azetidines by aza Paternò–Büchi reactions

A. D. Richardson, M. R. Becker and C. S. Schindler, Chem. Sci., 2020, Advance Article , DOI: 10.1039/D0SC01017K

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