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Dandelion flower-like micelles

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Abstract

Dandelion flower-like micelles (DFMs) were prepared by self-assembly of polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs). Upon reductive stimuli, the SCMs can be released from the DFMs by non-Brownian motion at an average speed of 19.09 μm s−1. Similar to the property of dandelion flowers dispersing their seeds over a long distance, the DFMs demonstrated enhanced multicellular tumor spheroid (MTS) penetration, a useful property in the treatment of many diseases including cancer, infection-of-biofilm diseases and ocular problems.

Graphical abstract: Dandelion flower-like micelles

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Publication details

The article was received on 13 Nov 2019, accepted on 23 Nov 2019 and first published on 03 Dec 2019


Article type: Edge Article
DOI: 10.1039/C9SC05741B
Chem. Sci., 2020, Advance Article
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Dandelion flower-like micelles

    Y. Yao, D. Xu, Y. Zhu, X. Dai, Y. Yu, J. Luo and S. Zhang, Chem. Sci., 2020, Advance Article , DOI: 10.1039/C9SC05741B

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