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Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

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Abstract

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.

Graphical abstract: Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

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Article information


Submitted
01 Nov 2019
Accepted
17 Dec 2019
First published
18 Dec 2019

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Advance Article
Article type
Edge Article

Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

R. Subiros-Funosas, V. C. L. Ho, N. D. Barth, L. Mendive-Tapia, M. Pappalardo, X. Barril, R. Ma, C. Zhang, B. Qian, M. Sintes, O. Ghashghaei, R. Lavilla and M. Vendrell, Chem. Sci., 2020, Advance Article , DOI: 10.1039/C9SC05558D

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