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Issue 12, 2020
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Selective glucose sensing in complex media using a biomimetic receptor

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Abstract

Glucose is a key biomedical analyte, especially relevant to the management of diabetes. Current methods for glucose determination rely on the enzyme glucose oxidase, requiring specialist instrumentation and suffering from redox-active interferents. In a new approach, a powerful and highly selective achiral glucose receptor is mixed with a sample, L-glucose is added, and the induced CD spectrum is measured. The CD signal results from competition between the enantiomers, and is used to determine the D-glucose content. The involvement of L-glucose doubles the signal range from the CD spectrometer and allows sensitivity to be adjusted over a wide dynamic range. It also negates medium effects, which must be equal for both enantiomers. The method has been demonstrated with human serum, pre-filtered to remove proteins, giving results which closely match the standard biochemical procedures, as well as a cell culture medium and a beer sample containing high (70 mM) and low (0.4 mM) glucose concentrations respectively.

Graphical abstract: Selective glucose sensing in complex media using a biomimetic receptor

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Supplementary files

Article information


Submitted
25 Oct 2019
Accepted
23 Feb 2020
First published
25 Feb 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020,11, 3223-3227
Article type
Edge Article

Selective glucose sensing in complex media using a biomimetic receptor

R. A. Tromans, S. K. Samanta, A. M. Chapman and A. P. Davis, Chem. Sci., 2020, 11, 3223
DOI: 10.1039/C9SC05406E

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