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Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging

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Abstract

Positron emission tomography (PET) molecular imaging is a powerful tool for interrogating physiological and biochemical processes to understand the biology of disease and advance therapeutic developments. Near-infrared fluorescence (NIRF) optical imaging has become increasingly popular for intraoperative staging to enable cellular resolution imaging of tumor margins during surgical resection. In addition, engineered antibody fragments have emerged as promising molecular imaging agents given their exquisite target selectivity, rapid systemic clearance and site-selective chemical modification. We report a tri-functional platform for construction of a modular antibody fragment that can rapidly be labeled with radionuclides or fluorophores for PET or NIRF molecular imaging of prostate stem cell antigen (PSCA).

Graphical abstract: Tri-functional platform for construction of modular antibody fragments for in vivo 18F-PET or NIRF molecular imaging

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Supplementary files

Article information


Submitted
04 Oct 2019
Accepted
30 Dec 2019
First published
07 Jan 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2020, Advance Article
Article type
Edge Article

Tri-functional platform for construction of modular antibody fragments for in vivo 18F-PET or NIRF molecular imaging

R. F. Gamache, K. A. Zettlitz, W. K. Tsai, J. Collins, A. M. Wu and J. M. Murphy, Chem. Sci., 2020, Advance Article , DOI: 10.1039/C9SC05007H

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