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Optimization, automation and validation of the large-scale radiosynthesis of Al18F tracers in a custom-made automatic platform for high yield

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Abstract

Al18F radiochemistry is a convenient 18F-labeling strategy with favorable characteristics, such as rapid chelation without complex chemistry, simple solid-phase purification and production of scalable doses. However, the commercially available synthesizers are preferred for 18F nucleophilic fluorination at milliliter-scale reaction volumes rather than radiochelation in aqueous solution. To address the problem, we have designed and assembled a custom-made automatic platform that is suitable for reliable Al18F radiochelation under conditions like small reaction volumes, heating under sealed conditions, and SPE-based purification. The automated platform, in general, works by four unit operations: (1) 18F trapping and elution, (2) radiolabeling in a small-volume reactor, (3) SPE purification, and (4) formulation and sterilization by terminal filtration. After the optimization of each unit operation, three representative Al18F tracers were produced in large scale in the range of 6.8–18.5 GBq at the end of synthesis (EOS) < 30 min, yielding isolated products with the decay-corrected radiochemical yields of 52 ± 6% for [18F]-Alfatide II, 67 ± 6% for [18F]-PSMA-11 and 45 ± 5% for [18F]-NOTA-Octreotide. The isolated RCYs were generally higher than those of the protocols operated in commercially available platforms and comparable to those of the processes implemented manually. All quality control tests met the criteria of the 2015 edition of the Chinese pharmacopoeia. Besides these three tracers, the production of other Al18F radiotracers in large radioactive batches would be convenient for multi-patient doses and off-site transportation, which would increase the potential for the clinical translation of Al18F tracers.

Graphical abstract: Optimization, automation and validation of the large-scale radiosynthesis of Al18F tracers in a custom-made automatic platform for high yield

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Supplementary files

Article information


Submitted
14 Apr 2020
Accepted
03 Jun 2020
First published
04 Jun 2020

React. Chem. Eng., 2020, Advance Article
Article type
Paper

Optimization, automation and validation of the large-scale radiosynthesis of Al18F tracers in a custom-made automatic platform for high yield

Z. Liu, L. Yu, K. Cheng, Y. Feng, P. Qiu, Y. Gai and M. Zhou, React. Chem. Eng., 2020, Advance Article , DOI: 10.1039/D0RE00144A

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