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Flow-controlled synthesis of gold nanoparticles in a biphasic system with inline liquid–liquid separation

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Abstract

We present the flow synthesis of 4-(dimethylamino)pyridine (DMAP)-stabilised gold nanoparticles in a biphasic flow reactor system. In the first stage, the reduction of gold chloride using sodium borohydride took place via gas permeable tubing to minimise pressure build-up in the lines due to hydrogen gas liberation. The use of liquid–liquid membrane separators enabled automatic washing of the intermediate tetraoctylammonium bromide (TOAB)-stabilised gold nanoparticles and for subsequent phase transfer of the organic nanoparticles to the aqueous phase using DMAP. Through a systematic investigation of DMAP concentration and ratio, the amount of DMAP necessary for full transfer of the gold nanoparticles was elucidated. This semi-automated, scalable flow process enabled the production of gold nanoparticles in high yield, with good batch-to-batch reproducibility and improved monodispersity compared to conventional batch methods.

Graphical abstract: Flow-controlled synthesis of gold nanoparticles in a biphasic system with inline liquid–liquid separation

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Article information


Submitted
21 Oct 2019
Accepted
18 Dec 2019
First published
02 Jan 2020

React. Chem. Eng., 2020, Advance Article
Article type
Paper

Flow-controlled synthesis of gold nanoparticles in a biphasic system with inline liquid–liquid separation

E. Chow, B. Raguse, E. Della Gaspera, S. J. Barrow, J. Hong, L. J. Hubble, R. Chai, J. S. Cooper and A. Sosa Pintos, React. Chem. Eng., 2020, Advance Article , DOI: 10.1039/C9RE00403C

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