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Advances in microbial production of medium-chain dicarboxylic acids for nylon materials

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Abstract

Medium-chain dicarboxylic acids (MDCAs) are widely used in the production of nylon materials such as nylon 5,6 and nylon 6,6, and among which, succinic, glutaric, adipic, pimelic, suberic, azelaic and sebacic acids are particularly important for that purpose, and also serve as platform chemicals for chemical, food, textile, pesticide, pharmaceutical and liquid crystal industries. Although most of these MDCAs are chemically synthesized, their biosynthesis has become more important due to the fast growth of biotechnology. Compared with chemical production and plant extraction, microbial-based production is more environmentally friendly and sustainable. In this review article, we critically comment existing methods for producing MDCAs and their biosynthesis, emphasizing metabolic engineering and synthetic biology strategies, which could help overcome barriers ahead and facilitate efficient bio-based production of MDCAs in the future.

Graphical abstract: Advances in microbial production of medium-chain dicarboxylic acids for nylon materials

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Publication details

The article was received on 15 Aug 2019, accepted on 31 Oct 2019 and first published on 31 Oct 2019


Article type: Review Article
DOI: 10.1039/C9RE00338J
React. Chem. Eng., 2020, Advance Article

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    Advances in microbial production of medium-chain dicarboxylic acids for nylon materials

    G. Li, D. Huang, X. Sui, S. Li, B. Huang, X. Zhang, H. Wu and Y. Deng, React. Chem. Eng., 2020, Advance Article , DOI: 10.1039/C9RE00338J

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