Issue 59, 2020

Microwave assisted synthesis of five membered nitrogen heterocycles

Abstract

Our continuously changing environment demands sensible and sustainable chemistry. Consequently, organic synthesis started to follow green chemistry principles in recent years. It is observed that microwave (MW) radiation has been widely used as a source of energy in organic synthesis in the past decade. The MW heating approach has evolved into a new green method in organic synthesis since it provides short reaction time, high yields, and high product purities along with a decrease in the rate of by-product formation. Solvent-free reaction protocols worked well under MW irradiation. All these features make MW assisted organic synthesis an environment-friendly approach. In organic synthesis, heterocycles are vital targets especially nitrogen-containing ones because of their prominent presence in natural products and widespread applications in pharmaceutical industries. Five membered nitrogen heterocycles include pyrroles, oxazoles, pyrrolidones, etc. among which pyrroles are the most important ones due to their potent biological properties. Even though there are a variety of reaction protocols for the synthesis of pyrroles, a significant development materialized in MW assisted synthesis of pyrroles in the past few years. In this review, we focus on the developments in MW assisted synthesis of pyrroles and other five-membered nitrogen heterocycles.

Graphical abstract: Microwave assisted synthesis of five membered nitrogen heterocycles

Article information

Article type
Review Article
Submitted
11 Jun 2020
Accepted
02 Sep 2020
First published
30 Sep 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 36031-36041

Microwave assisted synthesis of five membered nitrogen heterocycles

G. Meera, K. R. Rohit, S. Saranya and G. Anilkumar, RSC Adv., 2020, 10, 36031 DOI: 10.1039/D0RA05150K

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