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Issue 48, 2020, Issue in Progress
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Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases

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Abstract

A valid option to bypass the obstacle represented by the blood–brain barrier (BBB) in brain delivery is the use of the unconventional intranasal route of administration. The treatment of depressive diseases, resulting from the depletion of a neurotransmitter in the inter-synaptic space, such as serotonin, is indirectly treated using molecules that can permeate the BBB unlike the latter. In the present article, a set of nanovectors were produced using a mucoadhesive biopolymer, i.e. alginate (Alg). Optimizing the reaction, polymeric nanoparticles having diameter of 30–70 nm were produced, and water stable multi-walled carbon nanotubes functionalized (MWCNT-COOH)/Alg complexes were obtained. These nanovectors were loaded with serotonin, evaluating drug loading/release. By means of Raman microscopy, the cellular internalization of the (MWCNT-COOH)/Alg complex was demonstrated. A complete biocompatibility on neuronal cells was proved for the whole set of nanovectors. Finally, a method of self-administration was tested, which involves the use of a household apparatus, such as an aerosol machine, observing a fine particulate, able to deliver the nanovectors through the nose.

Graphical abstract: Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases

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Supplementary files

Article information


Submitted
11 May 2020
Accepted
26 Jul 2020
First published
04 Aug 2020

This article is Open Access

RSC Adv., 2020,10, 28941-28949
Article type
Paper

Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases

A. Sorrentino, A. Cataldo, R. Curatolo, P. Tagliatesta, L. Mosca and S. Bellucci, RSC Adv., 2020, 10, 28941
DOI: 10.1039/D0RA04212A

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