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Issue 45, 2020
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A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems

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Abstract

Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.

Graphical abstract: A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems

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Article information


Submitted
21 Apr 2020
Accepted
03 Jul 2020
First published
17 Jul 2020

This article is Open Access

RSC Adv., 2020,10, 26777-26791
Article type
Review Article

A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems

Y. Duan, A. Dhar, C. Patel, M. Khimani, S. Neogi, P. Sharma, N. Siva Kumar and R. L. Vekariya, RSC Adv., 2020, 10, 26777
DOI: 10.1039/D0RA03491F

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