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Issue 39, 2020, Issue in Progress
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High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids

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Abstract

Ionic liquids (ILs) have been employed as potentially environmentally friendly replacements for harmful organic solvents, but have also been studied for their use in bioelectrochemical applications, such as in microbial electrochemistry for bioenergy production, or in industrial biocatalysis. For these processes, low microbial toxicity is important and there is a growing need for microbial toxicology studies for novel ILs. In this study, we report initial toxicity data for novel ILs, based on azepanium and 3-methylpiperidinium cations. Agar disc diffusion assays are used, along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations, to obtain rapid and inexpensive initial toxicity data for these novel ILs against Escherichia coli and Staphylococcus epidermidis. Many of the novel ILs characterised possess low microbial toxicity relative to well-studied ILs, highlighting their potential for further study in applications where this is a desirable property.

Graphical abstract: High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids

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Supplementary files

Article information


Submitted
06 Apr 2020
Accepted
26 May 2020
First published
16 Jun 2020

This article is Open Access

RSC Adv., 2020,10, 22864-22870
Article type
Paper

High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids

A. L. Tether, G. Laverty, A. V. Puga, K. R. Seddon, B. F. Gilmore and S. A. Kelly, RSC Adv., 2020, 10, 22864
DOI: 10.1039/D0RA03107K

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