Issue 32, 2020

Recent applications of ninhydrin in multicomponent reactions


Ninhydrin (1,2,3-indanetrione hydrate) has a remarkable breadth in different fields, including organic chemistry, biochemistry, analytical chemistry and the forensic sciences. For the past several years, it has been considered an important building block in organic synthesis. Therefore, there is increasing interest in ninhydrin-based multicomponent reactions to rapidly build versatile scaffolds. Most of the works described here are simple reactions with readily available starting materials that result in complex molecular architectures. Some of the synthesized compounds exhibit interesting biological activities and constitute a new hope for anticancer agents. The present review aims to highlight the multicomponent reactions of ninhydrin towards diverse organic molecules during the period from 2014 to 2019.

Graphical abstract: Recent applications of ninhydrin in multicomponent reactions

Article information

Article type
Review Article
31 Mar 2020
24 Apr 2020
First published
18 May 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 18875-18906

Recent applications of ninhydrin in multicomponent reactions

S. Das, RSC Adv., 2020, 10, 18875 DOI: 10.1039/D0RA02930K

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