Issue 25, 2020, Issue in Progress

An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction

Abstract

New chiral bicyclic imines, enamines and amines were prepared via Horner–Wadsworth–Emmons reaction of hexahydroquinoxalin-2(1H)-one-derived phosphonate, as the source of a phosphonate carbanion, and a wide range of structurally diverse carbonyl substrates. The simplicity of the synthetic protocol, high selectivity, and broad substrate scope are the main advantages of the presented methodology.

Graphical abstract: An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction

Supplementary files

Article information

Article type
Paper
Submitted
07 Mar 2020
Accepted
26 Mar 2020
First published
09 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 14618-14629

An approach to new chiral bicyclic imines and amines via Horner–Wadsworth–Emmons reaction

J. Iwanejko, M. Sowiński, E. Wojaczyńska, T. K. Olszewski and M. Górecki, RSC Adv., 2020, 10, 14618 DOI: 10.1039/D0RA02646H

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