Coumarin-based fluorescent probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

Luling Wu; Xue Tian; Robin R. Groleau; Jie Wang; Hai-Hao Han; Shaun B. Reeksting; Adam C. Sedgwick; Xiao-Peng He; Steven D. Bull; Tony D. James

doi:10.1039/D0RA02234A

Coumarin-based fluorescent probe for the rapid detection of peroxynitrite ‘AND’ biological thiols†

Luling Wu,

‡*^a Xue Tian,

‡^a Robin R. Groleau,

^a Jie Wang,

^b Hai-Hao Han,

^b Shaun B. Reeksting,

^c Adam C. Sedgwick,

^d Xiao-Peng He,

^b Steven D. Bull

^a and Tony D. James

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk, lw960@bath.ac.uk

^b Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China

^c Materials and Chemical Characterization (MC2), University of Bath, Bath BA2 7AY, UK
Web: https://doi.org/10.15125/mx6j-3r54

^d Department of Chemistry, University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA

Abstract

A coumarin-based novel ‘AND’ logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO⁻ and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO⁻ analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

RSC Advances

Coumarin-based fluorescent probe for the rapid detection of peroxynitrite ‘AND’ biological thiols†

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Coumarin-based fluorescent probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

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