Issue 24, 2020

Synthesis of 3-selanylbenzo[b]furans promoted by SelectFluor®


A simple and practical protocol for the synthesis of 3-selanyl-benzo[b]furans mediated by the SelectFluor® reagent was developed. This novel methodology provided a greener alternative to generate 3-substituted-benzo[b]furans via a metal-free procedure under mild conditions. The intramolecular cyclization reaction was carried out employing an electrophilic selenium species generated in situ through the reaction between SelectFluor® and organic diselenides. The formation of this electrophilic selenium species (RSe-F) was confirmed by heteronuclear NMR spectroscopy, and its reactivity was explored.

Graphical abstract: Synthesis of 3-selanylbenzo[b]furans promoted by SelectFluor®

Supplementary files

Article information

Article type
28 Feb 2020
30 Mar 2020
First published
07 Apr 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 13975-13983

Synthesis of 3-selanylbenzo[b]furans promoted by SelectFluor®

M. C. Diem Ferreira Xavier, E. M. Andia Sandagorda, J. S. Santos Neto, R. F. Schumacher and M. S. Silva, RSC Adv., 2020, 10, 13975 DOI: 10.1039/D0RA01907K

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