Issue 20, 2020

Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings

Abstract

A variety of N-unprotected 2-amide-substituted indoles were synthesized from readily available furfural-based Ugi adducts in moderate to good yields via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings. These reactions involved a cascade sequence consisting of dearomatizing arylation, opening of the furan ring, and deprotection of the N atom.

Graphical abstract: Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings

Supplementary files

Article information

Article type
Paper
Submitted
17 Jan 2020
Accepted
28 Feb 2020
First published
23 Mar 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 11750-11754

Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings

H. Peng, K. Jiang, G. Zhen, F. Wang and B. Yin, RSC Adv., 2020, 10, 11750 DOI: 10.1039/D0RA01830A

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