Issue 21, 2020
From the journal:

RSC Advances

Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing†

Xiaomu Xu,‡ab   Yusheng Hu,‡bc   Li-peng Zhang,d   Bo Liu,b   Yue Yang,b   Taya Tang,b   Jijing Tian,b   Kaisong Peng*a  and  Tianlong Liu ORCID logo *b  

* Corresponding authors

a Laboratory of Aquatic Health and Public Health, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
E-mail: kaisongpeng@ahau.edu.cn

b Laboratory of Veterinary Pathology and Nanopathology, College of Veterinary Medicine, China Agricultural University, No. 2 West Road Yuanmingyuan, Beijing 100193, P. R. China

c College of Biological Sciences, China Agricultural University, No. 2 West Road Yuanmingyuan, Beijing 100193, P. R. China

d Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Haidian District, Beijing, China

Abstract

Effective wound healing has been demonstrated using lactic-co-glycolic acid (PLGA)-coated methylene blue nanoparticles (MPNPs) as a novel susceptible agent for photodynamic antibacterial therapy. Compared with methylene blue (MB) solution, MPNPs have a significantly improved antibacterial effect in vitro and in vivo. The enhanced antibacterial effect is achieved through increased singlet oxygen generation in MPNPs compared to that of MB solution, as a result of the decreased aggregation-induced quenching (ACQ) effect of the MPNPs. The mouse skin infection model experiment proved that MPNP has good antibacterial effects and promotes wound healing.

Graphical abstract: Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing

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Article information

DOI
https://doi.org/10.1039/D0RA01034K
Article type
Paper
Submitted
03 Feb 2020
Accepted
13 Mar 2020
First published
26 Mar 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 12304-12307

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Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing

X. Xu, Y. Hu, L. Zhang, B. Liu, Y. Yang, T. Tang, J. Tian, K. Peng and T. Liu, RSC Adv., 2020, 10, 12304 DOI: 10.1039/D0RA01034K

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