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Issue 9, 2020, Issue in Progress
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pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

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Abstract

Biodegradable nanoparticles (NPs) have shown great promise as intracellular imaging probes, nanocarriers and drug delivery vehicles. In this study, we designed and prepared amphiphilic cellulose derivatives via Schiff base reactions between 2,3-dialdehyde cellulose (DAC) and amino compounds. Polymeric NPs were facilely fabricated via the self-assembly of the as-synthesized amphiphilic macromolecules. The size distribution of the obtained NPs can be tuned by changing the amount and length of the grafted hydrophobic side-chains. Anticancer drugs (DOX) were encapsulated in the NPs and the drug-loaded NPs based on cellulose derivatives were stable in neutral and alkaline environments for at least a month. They rapidly decomposed with the efficient release of the drug in acidic tumor microenvironments. These drug-loaded NPs have the potential for application in cancer treatment.

Graphical abstract: pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

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Supplementary files

Article information


Submitted
07 Dec 2019
Accepted
10 Jan 2020
First published
29 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 4860-4868
Article type
Paper

pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

M. Kong, X. Peng, H. Cui, P. Liu, B. Pang and K. Zhang, RSC Adv., 2020, 10, 4860
DOI: 10.1039/C9RA10280A

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