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Issue 1, 2021
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Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications

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Abstract

The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydroxy-2-aryl acrylate is a vital precursor in the synthesis of natural products and in the development of essential drugs. In this first review, we outline different approaches for preparing 3-hydroxy-2-aryl acrylate with mechanisms and its application in a variety of chemical fields.

Graphical abstract: Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications

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Article information


Submitted
22 Sep 2020
Accepted
03 Nov 2020
First published
09 Nov 2020

Org. Chem. Front., 2021,8, 169-191
Article type
Review Article

Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications

M. Rahaman, M. S. Ali, K. Jahan, J. B. Belayet, A. F. M. T. Rahman and M. M. Hossain, Org. Chem. Front., 2021, 8, 169
DOI: 10.1039/D0QO01157F

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