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Transition-metal-free catalytic hydroboration reduction of amides to amines

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Abstract

The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation. Here, we present a combined KOtBu/BEt3 catalyst for the deoxygenative reduction of tertiary, secondary, and even notoriously challenging primary carboxamides with pinacolborane (HBpin) at 25–60 °C. This novel transition-metal-free methodology is readily applicable to the synthesis of drug molecules.

Graphical abstract: Transition-metal-free catalytic hydroboration reduction of amides to amines

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Article information


Submitted
07 Sep 2020
Accepted
29 Sep 2020
First published
30 Sep 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Transition-metal-free catalytic hydroboration reduction of amides to amines

W. Yao, J. Wang, A. Zhong, S. Wang and Y. Shao, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO01092H

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