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Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone

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Abstract

A new strategy for the construction of pertrifluoromethyl pyridazine derivatives is presented. The tandem reaction starts from the condensation of arenediazonium salts with hexafluoroacetylacetone leading to the formation of pertrifluoromethyl pyridazinols, which readily undergo electrophilic substitution reactions with phenols to afford benzo[5,6]chromeno[3,4-c]pyridazine products in the presence of concd H2SO4.

Graphical abstract: Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone

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Article information


Submitted
10 Aug 2020
Accepted
27 Sep 2020
First published
28 Sep 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone

W. Wu, X. Han and Z. Weng, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00955E

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