Pd/NBE-catalyzed sequential carbamoylation/olefination of aryl iodides

Abstract

We report a palladium/norbornene cooperative catalyzed ortho-carbamoylation/ipso-Heck cyclization of aryl iodides using alkene-tethered carbamoyl chlorides. This reaction was carried out using readily available starting materials under mild reaction conditions, and a variety of 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-one analogues were obtained in moderate to good yields.