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Issue 21, 2020
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Palladium-catalyzed carbonylative synthesis of arylacetamides from benzyl formates and tertiary amines

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Abstract

An efficient and straightforward palladium-catalyzed carbonylation of benzyl formates and tertiary amines has been explored. In this reaction, benzyl formates were successfully utilized both as CO surrogates and benzyl alcohol substrates, and a variety of arylacetamides were obtained in high yields with good functional group tolerance. Notably, tertiary amines were used as an amine source through a C–N bond cleavage pathway in the absence of additional oxidants.

Graphical abstract: Palladium-catalyzed carbonylative synthesis of arylacetamides from benzyl formates and tertiary amines

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Article information


Submitted
17 Jul 2020
Accepted
20 Sep 2020
First published
21 Sep 2020

Org. Chem. Front., 2020,7, 3406-3410
Article type
Research Article

Palladium-catalyzed carbonylative synthesis of arylacetamides from benzyl formates and tertiary amines

M. Lai, Z. Bao, X. Qi and X. Wu, Org. Chem. Front., 2020, 7, 3406
DOI: 10.1039/D0QO00854K

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