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Palladium-catalyzed one-pot cycloaddition reactions of thioureas with 3H-indol-3-ones generated in situ from 2-alkynyl arylazides: rapid and efficient access to imidazoloindolines

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Abstract

A novel and efficient palladium-catalyzed one-pot synthesis of imidazoloindolines from 2-alkynyl arylazides under mild reaction conditions has been described. This method features wide substrate applicability, resistance of water and air and excellent yields.

Graphical abstract: Palladium-catalyzed one-pot cycloaddition reactions of thioureas with 3H-indol-3-ones generated in situ from 2-alkynyl arylazides: rapid and efficient access to imidazoloindolines

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Article information


Submitted
05 Jul 2020
Accepted
22 Sep 2020
First published
23 Sep 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Palladium-catalyzed one-pot cycloaddition reactions of thioureas with 3H-indol-3-ones generated in situ from 2-alkynyl arylazides: rapid and efficient access to imidazoloindolines

P. Li, B. Zhu, Y. Xu, Z. Zhou, G. Hu, F. Yang, S. Xu and X. Zhang, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00799D

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