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Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae

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Abstract

Pleurocorols A (1) and B (2) with unprecedented carbon skeletons were isolated from the fruiting bodies of Pleurotus cornucopiae. The structures of compounds 1 and 2 were determined by using spectroscopic data and X-ray crystallography as 11(9 → 8)abeo-ergostane and 5(6 → 7), 11(9 → 7)diabeo-ergostane steroids, respectively. Their inhibitory effect on nitric oxide production and their cytotoxic activity against cancer cell lines were evaluated.

Graphical abstract: Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae

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Article information


Submitted
19 May 2020
Accepted
19 Jun 2020
First published
30 Jun 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Pleurocorols A and B: rearranged steroids from the fruiting bodies of Pleurotus cornucopiae

T. Kikuchi, M. Mori, Y. In, J. Zhang, T. Yamada and T. Hirano, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00605J

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