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Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution

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Abstract

A formal amide insertion and substitution reaction for the synthesis of functionalized isoindolin-1-ones was developed on the basis of graphene oxide (GO) as a green and oxidant-acid bifunctional carbon material. A series of N-acylisoindolin-1-ones were synthesized in good to excellent yields directly from benzoisofurans and nitriles in the presence of GO without the need for any additives or metals.

Graphical abstract: Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution

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Article information


Submitted
27 Apr 2020
Accepted
12 Jun 2020
First published
15 Jun 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution

X. Peng, D. Hu, P. Huang, H. Liao, Y. Zeng, Q. Liu and L. Liu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00498G

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