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Access to SCN-containing thiazolines via electrochemical regioselective thiocyanothiocyclization of N-allylthioamides

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Abstract

An electrochemical thiocyanothiocyclization of N-allylthioamides has been developed for the synthesis of SCN-containing 2-thiazolines. This method provides a green and efficient approach to generate 5-exo-cyclization 2-thiazolines with a broad substrate scope and good yields. In addition, 6-endo-cyclization isothiocyanato thiazines are formed regioselectively when cyclic thioamides are used as reactants. The reaction is easy to proceed under catalyst-, additive- and oxidant-free conditions.

Graphical abstract: Access to SCN-containing thiazolines via electrochemical regioselective thiocyanothiocyclization of N-allylthioamides

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Article information


Submitted
06 Mar 2020
Accepted
08 Apr 2020
First published
09 Apr 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Access to SCN-containing thiazolines via electrochemical regioselective thiocyanothiocyclization of N-allylthioamides

Y. Zhang, Z. Ding, P. Liu, W. Guo, L. Wen and M. Li, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00300J

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