Jump to main content
Jump to site search


Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction

Author affiliations

Abstract

A Michael addition-driven four-component reaction (4-CR) was developed for derivatizing chromones by strategically suppressing competing 4-CR Ugi reaction without a catalyst. A series of structurally diverse 4-oxochroman-2-carboxamides was synthesized with this one-pot protocol. In addition, the new reaction was expanded for the synthesis of a series of tetrazole substituted chromones by replacing carboxylic acid with trimethylsilyl azide (TMSN3). The imine functional group and the corresponding aldehyde hydrolysed from the imine were utilized for further structural diversification.

Graphical abstract: Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction

Back to tab navigation

Supplementary files

Article information


Submitted
30 Jan 2020
Accepted
04 Mar 2020
First published
06 Mar 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction

J. Lei, Y. Li, L. He, Y. Luo, D. Tang, W. Yan, H. Lin, H. Li, Z. Chen and Z. Xu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00145G

Social activity

Search articles by author

Spotlight

Advertisements