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Issue 7, 2020
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Nidulaxanthone A, a xanthone dimer with a heptacyclic 6/6/6/6/6/6/6 ring system from Aspergillus sp.-F029

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Abstract

Nidulaxanthone A (1), a xanthone dimer bearing an unprecedented heptacyclic 6/6/6/6/6/6/6 system, together with a new monomeric nidulalin D (2) and four known analogues (3, 4, 5 and 6), were isolated from Aspergillus sp. F029. Biosynthetically, 1 was likely generated via [4 + 2] cycloaddition of precursor 3. Compounds 1, 2, and 3 exhibited cytotoxicity with IC50 values ranging from 3.2 to 21.9 μM, and antibacterial activity with MIC50 values of 13.2 and 19.6 μg ml−1 for 2 and 3, respectively.

Graphical abstract: Nidulaxanthone A, a xanthone dimer with a heptacyclic 6/6/6/6/6/6/6 ring system from Aspergillus sp.-F029

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Supplementary files

Article information


Submitted
22 Jan 2020
Accepted
03 Mar 2020
First published
05 Mar 2020

Org. Chem. Front., 2020,7, 953-959
Article type
Research Article

Nidulaxanthone A, a xanthone dimer with a heptacyclic 6/6/6/6/6/6/6 ring system from Aspergillus sp.-F029

F. Wang, J. Jiang, S. Hu, X. Hao, Y. Cai, Y. Ye, H. Ma, W. Sun, L. Cheng, C. Huang, H. Zhu, H. Zhang, G. Zhang and Y. Zhang, Org. Chem. Front., 2020, 7, 953
DOI: 10.1039/D0QO00113A

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