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Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction

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Abstract

An Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction was discovered for the synthesis of indoline-piperidinones in one pot. A series of targeted compounds was prepared by means of a mild reaction and a simple operation procedure, which could be applicable to a broad scope of Ugi starting materials. This cascade reaction generates opportunities for the tailored synthesis of a wide range of indoline-piperidinone scaffolds through tuneable Ugi inputs.

Graphical abstract: Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction

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Article information


Submitted
08 Jan 2020
Accepted
20 Jan 2020
First published
22 Jan 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction

J. Lei, G. Song, Y. Luo, D. Tang, W. Yan, H. Li, Z. Chen and Z. Xu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00028K

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